Apolipoprotein E Genotype Linked to Spatial Gait Characteristics: Predictors of Cognitive Dual Task Gait Change
نویسندگان
چکیده
BACKGROUND Developing measures to detect preclinical Alzheimer's Disease is vital, as prodromal stage interventions may prove more efficacious in altering the disease's trajectory. Gait changes may serve as a useful clinical heuristic that precedes cognitive decline. This study provides the first systematic investigation of gait characteristics relationship with relevant demographic, physical, genetic (Apolipoprotein E genotype), and health risk factors in non-demented older adults during a cognitive-load dual task walking condition. METHODS The GAITRite system provided objective measurement of gait characteristics in APOE-e4 "carriers" (n = 75) and "non-carriers" (n = 224). Analyses examined stride length and step time gait characteristics during simple and dual-task (spelling five-letter words backwards) conditions in relation to demographic, physical, genetic, and health risk factors. RESULTS Slower step time and shorter stride length associated with older age, greater health risk, and worse physical performance (ps < .05). Men and women differed in height, gait characteristics, health risk factors and global cognition (ps < .05). APOE-e4 associated with a higher likelihood of hypercholesterolemia and overall illness index scores (ps < .05). No genotype-sex interactions on gait were found. APOE-e4 was linked to shorter stride length and greater dual-task related disturbances in stride length. CONCLUSIONS Stride length has been linked to heightened fall risk, attention decrements and structural brain changes in older adults. Our results indicate that stride length is a useful behavioral marker of cognitive change that is associated with genetic risk for AD. Sex disparities in motor decline may be a function of health risk factors.
منابع مشابه
فعالیت عضلانی سالمندان دارای ضعف تعادلی در همراه با تکلیف دوگانه
Objectives: Each step during gait requires different attention demands that will affect muscles activity. The study of changes in the timing and intensity of the muscles activity in walking with dual task has received less attention from researchers. The purpose of this study was to evaluate changes in electromyography patterns of gait with cognitive dual tasks in balance impaired elderly. M...
متن کاملThe Effect of Dual Motor-cognitive Task Training on Inter-join Coordination during Walking in Elderly with Balance Impairment
Introduction: In recent years, the effect of cognitive exercises on improving gait parameters has been studied, but the effects of these exercises on coordination inter-joint of the lower limbs have received less attention. Therefore, the aim of this study was to investigate the effect of dual task motor-cognitive training on inter-join coordination during walking in elderly with balance impair...
متن کاملThe Effect of Dual Task Interference on Gait in Aging: Role of Working Memory Components
The purpose of the present study was to investigate the effect of concurrent cognitive tasks activating phonological loop and visuospatial scratchpad of working memory on gait in older adults.12 older adults with the age range of 65-70 years performed walking trials in 3 counterbalanced testing conditions including single walking, walking while performing visuospatial task and walking while per...
متن کاملThe Effects of Counting the Stride Numbers on the Parkinsonian Gait: Suggesting a Possible Reason for Dual Task Interference
Introduction: Parkinson Disease (PD) is a degenerative and progressive disorder of the central nervous system. It results from degeneration of Substantia Nigra pars compacta (SNc) of the Basal Ganglia (BG). Gait disturbances in PD patients generally get worse over time. The underlying mechanism of gait disturbances in PD has not been elucidated yet. Methods: In this study, we tried to analyze ...
متن کاملThe Effect of Cognitive and Motor Dual-task Training on Improvement of Balance and Some Spatiotemporal Gait Parameters in People With Idiopathic Parkinson\'s Disease
Background: Parkinson Disease (PD) is characterized by motor and non-motor symptoms that affect patients’ functions, especially while performing dual tasks--a critical factor in everyday living. However, many controversies exist about the benefits of dual-task training in patients with PD. Objectives: This study assessed the efficacy of motor and cognitive dual-task training in improving balanc...
متن کامل